The Integrated Technology Resource for Biomedical Glycomics was established in 2004 with funding from the National Center for Research Resources to develop and implement new technologies to investigate the Glycome of cells and exploit the use of these technologies to develop embryonic stem cell markers during their differentiation. More ....
News ...

Results of recent research performed by scientists at the Glycomics Resource to be presented at Glycobiology 2007 in Boston.    More...

Training courses for glycomics and glycoproteomics analysis are open for enrollment.    More...

Click the image below to view our movie of beating myocytes generated by differentiation of embryonic stem cells.


Stem Cells
Stem Cell Platform: This Core is responsible with growth and differentiation of the various stem cells undergoing analysis by the Resource, including monitoring of precise differentiation states by analysis of various transcripts by qRT-PCR. In addition, this group also studies presentation of various cell surface glycans using lectin and antibody histochemical and flow cytometric analyses.

Glycomics
Glycoproteomics and Glycoconjugate Analysis: This research group focuses on developing technologies for the determination of the details of glycan expression on glycoproteins and glycolipids. These details include the glycan structural analysis, identification of the proteins that express different types of glycans, and characterization of the sites on proteins to which particular glycans are attached. Glycosphingolipid analysis is also performed by this Core.

Transcriptomics
Transcript Analysis by qRT-PCR: This research group has developed a qRT-PCR analysis platform for the analysis of transcripts encoding >750 genes that function in glycan biosynthesis, catabolism, and recognition in both mouse and humans, including ~250 glycosyltransferase transcripts. The platform has proven to be robust, flexible, and highly-sensitive for transcript analysis of mouse and human cell and tissue sources.

Bioinformatics
Bioinformatics The bioinformatics group provides the computational framework required interpret data generated by scientists of the Resource Center and to make this information available in a form that is transparent to scientists with expertise in a broad range of disciplines.

Service
Service and Training: The Glycomics Resource offers a comprehensive service program for structural characterization of native and recombinant glycoproteins and glycolipids using combination of analytical techniques. We also offer several annual hands-on training courses on glycoconjuagte structural analysis.

Collaborations
Collaborations: The resource has established many collaborations, including nine formal collaborations. Click now to see a brief description of each of these collaborations.

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